Formulation, Physical Stability Test and Irritation Test of Preparation of Gambir Leaf (Ucaria Gambir Roxb.F) Leaves Extract Nanogel Medicine

Abstract

Gambir leaves (Uncaria gambir Roxb.) are widely available in Indonesia, especially on the island of Sumatra. Gambir leaf extract (Uncaria gambir Roxb.) if used topically is less desirable by the public because it smells languorous or herbal.  In addition, secondary metabolites of catechins found in gambier leaves have low bioavailability. Nanogels are nanoscale particles produced by three-dimensional cross-linked polymers with hydrophilic or amphiphilic macromolecular chains that can be ionic or non-ionic. This research began with making gambier leaf extract which was then made into nanogel preparations with concentrations of 1%, 2% and 3%. Physical evaluation of nanogel preparations in the form of organoleptic, homogeneity, pH, adhesion, viscosity, particle size and zeta potential. The results obtained were a brownish orange nanogel preparation with a pH between 4.5 to 6.5 and was homogeneous. The highest adhesion results were found at F3 (1.752 ± 0.037) cm with a zeta potential value and particle size of 30.6 ± 0.17 mV 142.567 ± 0.3055 nm. The conclusion obtained in this research is that the 3% concentration of gambier leaf extract nanogel preparation has the best results in terms of physical evaluation compared to other concentration nanogel preparations.